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Pharmacologia Vol. 3 (8), 2012
Research Article
Anti-anxiety and Anti-depressant Activity of Leaves of Alstonia scholaris Linn. R.Br.
S.Arulmozhi , P.M.Mazumder , L. Sathiyanarayanan and Prasad A. Thakurdesai
 
Abstract: Background: The antianxiety activity of the ethanolic extract of leaves of Alstonia scholaris (Family: Apocynaceae) has been well established. The objective of the present study is to evaluate the anti-anxiety activity of the ethyl acetate fraction from ethanolic extract of leaves of Alstonia scholaris. Materials and Methods: EA fraction from Alstonia scholaris was tested against various anti-anxiety models viz. elevated plus maze, open field, hole board, light dark and mirror chamber and foot shock induced aggression models. The change in brain monoamines was estimated. The possible serotonergic effect was tested by 5-Hydroxy Tryptophan (5-HTP) induced wet dog shake, tail suspension and modified forced swim tests. Results: EA was found to be significantly active in open filed test, foot shock induced aggression and mirror chamber models of anxiety. However, lack of activity in elevated plus maze, light dark box, hole board test models, decrease in spontaneous motor activity, potentiation of 5-HTP, increase in 5-hydroxy tryptamine in brain indicate EA to have serotonergic effects. Decrease in immobility time in tail suspension test which was inhibited by reserpine and increase in swimming behaviour in forced swim test were conclusive evidence of selective serotonin reuptake inhibition. Conclusion: The present study suggest that EA possess antianxiety and antidepressant activity. The apparent mechanism of action is selective serotonin reuptake inhibition.
 
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