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Pharmacologia Vol. 3 (1), 2012
Research Article
Hepatoprotective Activity of Fumaria officinalis against CCl4-induced Liver Damage in Rats
UdayRaj Sharma , T.Prakash , V.Surendra , N. Roopakarki and Divakar Goli
Abstract: Background: Hepatoprotective activity of Fumaria officinalis of ethanolic extract were studied using carbon tetrachloride (CCl4) induced liver damage in rats. Liver damage was achieved by injecting 0.8 mL kg-1, s.c. of CCl4 in diluted with 30% solution of liquid paraffin. Result: The ethanolic extract at a dose of 200 and 500 mg kg-1, p.o. offered significant (p<0.001) hepatoprotective action by reducing the serum marker enzymes like SGPT, SGOT, ALP. They also reduced the elevated levels of serum total and direct bilirubin, cholesterol, triglycerides. Ascorbic acid estimation in rat’s urine and histophathological studies further conform the hepatoprotective activity of Fumaria officinalis when compared to the CCl4 treated control groups. The results obtained were compared with Silymarin (100 mg kg-1, p.o.), the standard drug. Conclusion: In conclusion, ethanolic extract of Fumaria officinalis showed significant hepatoprotective activity.
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