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Pharmacologia Vol. 4 (3), 2013
Research Article
Preventive and Therapeutic Efficacies of Benincasa hispida and Sechium edule Fruit’s Juice on Sweet-beverages Induced Impaired Glucose Tolerance and Oxidative Stress
Ashok KumarTiwari , IragavarapuAnusha , MaddineniSumangali , Domati AnandKumar , Kuncha Madhusudana and Sachin Bharat Agawane
Abstract: Aim: Increased consumption of sugar-sweetened beverages have been identified as one of the major sources responsible for increasing global epidemic of hyperglycemia, hyperglycemia induced oxidative stress and consequently, development of number of diabetic complications. This research explored preventive and therapeutic potentials of fruit juice of Benincasa hispida (BH) and Sechium edule (SE) in fructose and sucrose-sweetened beverages induced Impaired Glucose Tolerance (IGT), oxidative stress and IGT induced other metabolic disturbances in rats. Materials and Methods: Rats were orally administered fructose and sucrose sweetened-beverage prepared in water and respective fruit’s juice for one month. A group of rats were maintained for three months on daily single dose of sucrose. Three months sucrose-fed rats were later treated with fruit’s juice for fifteen days. Degree of IGT development was determined following Oral Glucose Tolerance Test (OGTT). Shape of plasma glucose concentration curve following OGTT, glycemic load, plasma Total Antioxidant Potential (TAOP), oxidative stress status, platelet aggregation activity and, Advanced Glycation End-products (AGEs) level in blood of rats were examined. Results: Fructose was more potent in inducing IGT than sucrose. Sucrose was more potent in decreasing plasma TAOP and inducing oxidative stress than fructose. BH juice prevented development of IGT induced by fructose and also significantly (p<0.05) reduced two hour glycemic load following OGTT. Three months continuous single dose administration of sucrose in rats induced development of IGT, increased two hour glycemic load (p<0.05) following OGTT, decreased TAOP (p<0.05), increased oxidative stress (more than twice) when compared with normal rats. Treatment of theses rats with juice of BH and SE accelerated normalization of oral glucose tolerance ability and decreased oxidative stress, platelet aggregation and accumulation of AGEs in sucrose induced IGT and oxidatively stressed rat. Conclusion: Our observations reveal that consumption of BH and SE juice may help reduce development of hyperglycemia and hyperglycemia induced development of complications by virtue of their antihyperglycemic and antioxidative stress potentials.
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