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Pharmacologia Vol. 5 (5), 2014
Research Article
Diuretic Activity and Toxicological Assessment of the Aqueous Extract from the Aerial Part of Commelina diffusa (Commelinaceae) in Rats
Sylvie LeaWansi , Serges KamdemDjoko , Albert DonatienAtsamo , Rodrigue AkoueNgape , Elvine PamiNguelefack-Mbuyo , ChristianFofie , HubertDonfack , Telesphore Benoit Nguelefack and Albert Kamanyi
Abstract: Background: Commelina diffusa (C. diffusa) is a plant, traditionally used in Africa and Asia to treat hypertension, pain and renal diseases. The aim of the present study was to evaluate the diuretic potential and toxicological profile of the aqueous extract from the aerial part of Commelina diffusa (AECD). Materials and Methods: The aqueous extract was prepared by decoction of the powder obtained from the aerial part of C. diffusa and administered orally at the doses 100 and 200 mg kg-1 b.wt. for the study of diuretic activity in male rats. For the acute toxicity study 1.5, 3, 6 and 12 g kg-1 b.wt. were used, while 150, 300 and 600 mg kg-1 b.wt. were used for the sub chronic toxicity study in mice for 4 weeks. Furosemide, the reference drug (20 mg kg-1), was used as the positive control during the experiment. Blood sample collected was used to evaluate the concentrations of total proteins, creatinin and liver transaminases: Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST), while the urine sample collected was used to evaluate Na+, K+ and creatinin concentrations. Results: After acute and 7 day subchronic diuretic study, AECD at all doses and furosemide produced important and significant increments in urinary excretion of water and sodium in rats with respect to control group. AECD also induced K+ excretion increased but it was no significant and less than the one induced by furosemide. During the toxicity study, period, AECD may be devoided of acute toxicity and any other adverse effects, however, subchronic toxicity study revealed a significant increase in water consumption, ALT concentration and total proteins in serum. Conclusion: The strong diuretic, natriuretic properties and its K+ sparing effect make the AECD to be regarded as a good diuretic confirming their ethno pharmacological use. Also, AECD was found to be practically nontoxic.
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