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Pharmacologia Vol. 6 (1), 2015
Research Article
Anti-Stress Activity of Phloroglucinol: A Transient Metabolite of Some Plant Polyphenolics
Binod KumarRauniyar , AnshulShakya , Ajit KumarThakur , Shyam Sunder Chatterjee and Vikas Kumar
Abstract: Background and Objectives: Phloroglucinols are secondary metabolites that occur naturally in certain plant species. Microorganisms such as brown algae or bacteria also produce phloroglucinols. Phloroglucinols has potential health effect and it is used as a treatment for gallstones, spasmodic pain and other related gastrointestinal disorders. The objective of the study was to evaluate phloroglucinol and its tri-methyl ether for anti-stress activity and its beneficial effect on stress-induced perturbations. Method: Stress-induced hyperthermia and pentobarbital sedation models were used for pilot study cum relative dose response study at single and repeated per-oral doses of 3-300 mg kg‾1 day‾1. Further study was performed to evaluate phloroglucinol (1-16 mg kg‾1 day‾1, p.o., for 7 days) for anti-stress activity using validated animal models of stress viz., foot-shock stress and cold-restraint stress. Stress-induced perturbations were evaluated in stressed rats by using sexual behaviour, elevated zero maze and behavioural despair tests. Results: The observations revealed that phloroglucinol and its tri-methyl ether protect mice against stress-induced hyperthermia only after its daily administrations. After fairly low oral doses, phloroglucinol inhibited not only stress-induced gastric ulcers but also the exaggerated anxiety and depression observed in stressed animals. In the same dose range, it also improved sexual behaviour and suppressed adrenal hypertrophy and spleen atrophy in stressed animals. Conclusions: These observations strongly suggest that plasma or urinary levels of phloroglucinol are not proper indicators of its therapeutic benefits and that its observed anti-stress activity could as well be due to its actions on the microbiota-gut-brain axis.
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