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Pharmacologia Vol. 7 (2-3), 2016
Research Article
Ameliorative Effect of Ferulic Acid Against Acetic Acid Induced Ulcerative Colitis: Role of HO-1 and Nrf2
Amit D.Kandhare , AnaghaPatil , AnamikaGuru , AnweshaMukhrjee , SandipanSarkar , AntaraSengupta , Hari MohanParmar , Amol P.Muthal , Pralhad Wangikar and Subhash L. Bodhankar
Abstract: Background: Inflammatory Bowel Disease (IBD) is a chronic disease of unknown etiology, which is characterized by chronic and spontaneously relapsing inflammation. Objective: To evaluate the effect of ferulic acid on acetic acid-induced IBD in rats. Materials and Methods: Ulcerative colitis was induced in male Wistar rats (180-220 g) by intrarectal instillation of 2 mL of 4% (v/v) acetic acid solution. Rats were treated orally with either ferulic acid (10, 20 and 40 mg kg–1, p.o.), prednisolone (2 mg kg–1) or distilled water (10 mg kg–1). Various biochemical, molecular and histological parameters were evaluated. Results: Intrarectal administration of 4% acetic acid resulted in significant alteration (p<0.05) in ulcer area, serum alkaline phosphatase, serum lactate dehydrogenase and colonic superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) content. Administration of ferulic acid (20 and 40 mg kg–1) significantly (p<0.05) ameliorated these acetic acid-induced alterations. There was a significant (p<0.05) down-regulation in colonic HO-1 mRNA expression, which was significantly up-regulated (p<0.05) by ferulic acid (20 and 40 mg kg–1). The decreased colonic Nfr2 level after acetic acid instillation was increased by ferulic acid (20 and 40 mg kg–1) treatment, which was revealed by immunohistochemical analysis. Histological aberration induced after acetic acid instillation was inhibited by ferulic acid. Conclusion: The findings of the present investigation showed that ferulic acid has an anti-inflammatory and anti-oxidant potential to inhibit acetic acid-induced colitis via upregulation in the HO-1 and Nrf-2 expressions.
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