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Pharmacologia Vol. 8 (2), 2017
Short Communication
Thrombolysis Potential of Methanol Extracts from the Five Medicinal Plants Leaf, Available in Bangladesh
Md. Jakaria , Mukimul Islam , Md. Shariful Islam , Mohammad Belal Talukder , Chayan Dhar Clinton and Mohammed Ibrahim
Abstract: Background and Objective: Blood clots block the blood vessels due to the several reasons that might be leading to the several cardiovascular and cerebrovascular disorders. Considering the adverse effects of modern medicine, the discovery and development of drugs by utilizing the medicinal plant sources are an alternative option. The present study was carried out to compare the thrombolysis activity among the five different methanol extracts from the five Bangladeshi medicinal plants. Materials and Methods: An in vitro thrombolytic model was used to investigate the clot lysis activity of medicinal herbs using streptokinase as a positive control and water as a negative control. In brief, venous blood drawn from ten healthy volunteers was permitted to form clots which were weighed and treated with the test plant extracts to disrupt the clots. Weight of clot after and before treatment presented a percentage of clot lysis. Statistical comparisons were performed using one-way ANOVA followed by Tukey/Tukey-Kramer (equal/unequal observations). Results: Among the all tested herb extracts, the maximum percentage of clot lysis activity was reached by Jacquemontia paniculata (J. paniculata) (60.753%) and P. adenophylla (54.057%), respectively. In this study, all of the herb extracts showed very significant (p<0.001) clot lysis activity compared with streptokinase as a positive control. Conclusion: On the basis of the experiment, all methanol extracts of the medicinal plants possessed blood clots lysis activity.
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